領(lǐng)學術(shù)科研之先,創(chuàng)食品科技之新
—— 中國食品雜志社
期刊集群
Application of in vitro and in vivo models in the study of food allergy
來源:食品科學網(wǎng) 閱讀量: 363 發(fā)表時間: 2019-09-25
作者: Jianjian Huanga, Changjun Liuc, Yanbo Wanga,b, Chong Wanga, Menghua Xiea, Yi Qiana,Linglin Fua,b,?
關(guān)鍵詞: Food allergy,Cell model,Animal model,Zebrafish,Clinical study
摘要:

Food allergy is one of the most important food safety problems that has attracted increasing attention.

The food allergy experimental models provide not only the accurate allergen detection and evaluation

methods but also the powerful approaches for mechanism investigations. In this paper, we reviewed the

common food allergy cell models including mast cell, basophil granulocyte and basophil, as well as the

animal models of BALB/c mouse, C3H/HeJ mouse, and BN rat. We also introduced zebrafish, a promising

model organism for investigating immunity though lacking direct applications in food allergy to date, and

focused on traumatic inflammation, bacterial infection and viral infection models. In addition, we also

summarized the clinical diagnostic research methods for food allergy. The elucidation of these topics will

help researchers to understand the characteristics and mechanisms of various models and thus select

the proper models for particular study, so as to support further investigations of food allergy.

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